Activation of Cyclin-Dependent Kinase 5 Mediates Orofacial Mechanical Hyperalgesia
نویسندگان
چکیده
منابع مشابه
Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia
BACKGROUND Cyclin-dependent kinase 5 (Cdk5) is a unique member of the serine/threonine kinase family. This kinase plays an important role in neuronal development, and deregulation of its activity leads to neurodegenerative disorders. Cdk5 also serves an important function in the regulation of nociceptive signaling. Our previous studies revealed that the expression of Cdk5 and its activator, p35...
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Regulation of the process of neuronal death plays a central role both during development of the CNS and in adult brain. The transcription factor myocyte enhancer factor 2 (MEF2) plays a critical role in neuronal survival. Cyclin-dependent kinase 5 (Cdk5) mediates neurotoxic effects by phosphorylating and inhibiting MEF2. How Cdk5-dependent phosphorylation reduces MEF2 transactivation activity r...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2013
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-9-66